Protopic skin cream is a drug that is applied to the skin that is used for the treatment of atopic dermatitis or eczema. Atopic dermatitis is a chronic disease of skin in which the skin becomes inflamed, causing itchiness, redness, swelling, and cracking, weeping, crusting, and scaling. Protopic skin cream has the composition of Tacrolimus in it, which is a prescribed medication for treating eczema. Protopic skin cream ointment suppresses the immune system and the inflammation by inhibiting an enzyme crucial for the multiplication of T-cells, cells that are required for activation of the immune system.

Protopic skin cream ointment was approved for the treatment of atopic dermatitis in December 2000. Eczema is an allergic-type condition that causes red, irritated, and itchy skin. This drug works by weakening the skin’s immune system, thereby decreasing the allergic reaction and relieving the eczema. Protopic skin cream belongs to a class of drugs known as topical calcineurin inhibitors (TCIs).

How to use Protopic Cream

Wash your hands with soap and water before using this medication. Apply a thin layer to the affected areas of skin, usually twice daily or as directed by your doctor. Rub the medication into the skin gently and completely. Wash your hands after using this product unless your hands are being treated. If your doctor recommends a moisturizer, apply it after this medication. This product is for use on the skin only. Avoid getting this medication in your eyes or on the inside of your nose or mouth. If you do get the medication in those areas, flush with plenty of water. Do not apply this medication to open wounds or infected areas. Do not cover the treated area with plastic or waterproof bandages unless directed to do so by your doctor. Do not bathe, shower, or swim right after applying this medication.

Cautions before Use Protopic Cream

The cautions, which are to be followed, are as follows with Protopic skin cream:

  • There have been rare reports of cancers such as skin cancer and lymphoma in patients using Protopic
  • Before using Protopic, tell your doctor or pharmacist if you are allergic to it; or to other macrolide medications such as sirolimus,erythromycin, clarithromycin, azithromycin or if you have any other allergies.
  • People with a history of kidney problems
  • People with a history of herpes and shingles
  • People with a history of swollen lymph nodes
  • Problems with light therapy such as UVA and UBV

Protopic Cream Side effects

The side effects, which may occur due to the use of Protopic, are as follows:

  • Redness itching on the skin
  • Sore throat
  • Fever
  • Upset stomach
  • Muscle pain
  • Chest Pain
  • Shingles
  • Warts
  • Severe dizziness
  • Swelling on face, tongue and mouth
  • Trouble in breathing

Protopic Cream Reactions and overdose

Before using this medication, ask your doctor or pharmacist about all prescribed drugs and nonprescribed or herbal products you are using as it may cause reactions with them. It is better not to use any kind of medicines like itraconazole, ketoconazole, macrolide antibiotics including clarithromycin, erythromycin, protease inhibitors and blockers including diltiazem, verapamil, ziprasidone.
Dangerous overdose affects may rise if swallowed, if this happens the patient must seek medical care.


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