Generic Name:Thioguanine

Thioguanine is a prescribed medication used to treat cancer. Thioguanine delays with the growth and spread of cancer cells in the body. This medication is used along with other drugs to treat a certain type of cancer known as acute nonlymphocytic leukemia. The active ingredient of Thioguanine belongs to a class of drugs known as purine antagonists. It works by slowing or stopping the growth of cancer cells.

How to Use Thioguanine Tablets

  • Take this medication by mouth with or without food with a full glass of water usually once daily or as directed by your doctor.
  • Properly discard any unused medication
  • Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Doing so may help decrease the risk of side effects such as, kidney stones.
  • The dosage is based on your body weight, medical condition, and response to treatment. Do not increase your dose or take this medication more often than prescribed.
  • Your condition will not improve any faster, and the risk of serious side effects may be increased.

Cautions before Use Thioguanine Tablets

  • Before taking this medicine, consult your doctor or pharmacist if a certain drug such as mercaptopurine did not work for you in the past. This may affect how well Thioguanine works for you.
  • People with a medical history, especially of other blood disorders such as anemia, low blood cell counts should not use Thioguanine.
  • People suffering from gout should not take this medicine.
  • Those patients who have medical history of kidney stones should not take this medicine.
  • People who have complains of liver problems are suggested to not to take this medicine.
  • People with a certain inherited problem lack of thiopurine methyltransferase-TPMT enzyme may be at increased risk for serious side effects from this medication and may require dosage adjustment.
  • Since this drug may be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Thus, this medication is not recommended for use during pregnancy. It may harm an unborn baby.

Thioguanine Tablets Side Effects

The side effects which may arise due to the usage of Thioguanine are as follows;

  • Vomiting, mild diarrhea
  • Hair loss
  • Mild itching or skin rash
  • Darkened skin color
  • Pale skin
  • Feeling light-headed or short of breath
  • Rapid heart rate, trouble concentrating
  • Fever, chills, body aches, flu symptoms
  • Sores or white patches in your mouth and throat
  • Easy bruising, unusual bleeding from nose, mouth, vagina, or rectum
  • Purple or red pinpoint spots under your skin
  • Severe vomiting, ongoing diarrhea
  • Severe pain in your upper stomach spreading to your back, fast heart rate;
  • Bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • Nausea, upper stomach pain
  • Loss of appetite, dark urine, clay-colored stools
  • Jaundice

Interactions and Overdose of Thioguanine Tablets

Thioguanine may react with especially of: aminosalicylates such as olsalazine, mesalazine, sulphasalazine, drugs that may affect bone marrow such as azathioprine, drugs that contain trimethoprim, other anti-cancer drugs, drugs that may affect the liver such as amiodarone, erythromycin, busulfan.

Symptoms of overdose of Thioguanine may include nausea, vomiting, diarrhea, unusually heavy sweating. In these situations people should take immediate medical support.


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