Generic Name:Thiotepa

Thiotepa is a prescribed medication used for cancer. It is known as an antineoplastic medication. Thiotepa interferes with the growth of cancer cells and slows their growth and spread in the body. It works by slowing or stopping the growth of cancer cells. Thiotepa is often given into the bladder to treat bladder cancer. Thiotepa is used in the treatment of cancers of the breast, ovary, and others.

How to Use Thiotepa Injections

  • This medication is given by injection into a vein by a health care professional, usually once a week or as directed by your doctor. Sometimes, thiotepa is injected directly into the tumor.
  • For treatment of bladder cancer, thiotepa is usually given into the bladder through a tube or a catheter. Your doctor may direct you to limit fluids for 8 to 12 hours before the medication is given.
  • The solution is usually left in place for 2 hours and then drained out through the bladder tube. Your doctor may direct you to change positions every 15 minutes while the solution is in your bladder to make sure the solution treats all parts of your bladder.
  • The first dosage of the medication is given is based on your medical condition and response to treatment. Your doctor will do blood tests (complete blood count) to find the right dose.
  • Your second dose may need to be rescheduled if your white blood cell count or platelets are too low. You should know how to handle, use, and discard chemotherapy and medical supplies safely and you should wash your hands very well after using any such kind of medications.

Cautions before Use Thiotepa Injections

  • People suffering from any bone marrow diseases are advised to not to take this medication at all.
  • Patients who have a medical history of liver diseases are restricted from using this medication.
  • People suffering from kidney diseases are restricted from using Thiotepa.
  • People who have a problem of low white blood cell count/platelets from previous chemotherapy or radiation treatment they are not allowed to not to take this medication.
  • This medication is not used for pregnant women as it may harm the unborn child.

Thiotepa Injections Side Effects

The side effects which may arise due to the usage of Thiotepa are as follows:

  • Fatigue or weakness
  • Mild to moderate nausea
  • Vomiting and loss of appetite
  • Redness or inflammation of the eyes
  • Dizziness and headache
  • Blurred vision
  • Temporary hair loss
  • A loss of skin coloration
  • Decreased menstruation in women and decreased sperm production in men
  • Liver Damage
  • Allergic Reactions
  • Tissue damage
  • Fever
  • Difficulty in Urination

Interactions and Overdose of Thiotepa Injections

Thiotepa may interact with aspirin and other NSAIDs such as ibuprofen, drugs that may harm the immune system such as chemotherapy, corticosteroids such as prednisone), live virus vaccines like oral polio vaccine, flu vaccine inhaled through the nose), nalidixic acid.Make sure to check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin if taking along with this medication.

In case of overdose people should contact their healthcare provider immediately.


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