Velcade

Generic Name: Bortezomib

Velcade is a prescribed medicine used in the treatment of cancer. It comes in the form of injection contains the active ingredient of Bortezomib, which is a type of medicine called a proteasome inhibitor. It is used to treat multiple myeloma, which is a cancer of a type of white blood cell in the bone marrow. In multiple myeloma, white blood cells called plasma cells multiply in an uncontrolled way.

Proteasomes are enzymes that are involved in the normal function and growth of cells. Velcade inhibits the function of the proteasomes in the cancerous plasma cells. This affects the normal functioning and growth of these cells and results in the death of the cancer cells. Velcade is used to treat multiple myeloma and mantle cell lymphoma. It is sometimes given after other cancer medications have been tried without successful treatment. Cancer cells seem to be more sensitive to the effects of Velcade than normal healthy cells.

How to Use Velcade Injection

  • Velcade is injected into a vein through an IV.
  • You will receive this injection in a clinic or hospital
  • Velcade is usually injected 2 times a week for 2 weeks, followed by 10 days without an injection. Velcade may also be given once a week for 4 weeks followed by 13 days without an injection. Follow your doctor’s instructions about your individual dosing schedule.
  • This medicine has not been recommended in children and adolescents under 18 years of age.

Cautions before Use Velcade Injection

  • People having kidney or liver problems cannot take this medicine.
  • People with a history of or increased risk of seizures or fits, or fainting in epilepsy are not allowed to take this medicine.
  • Disorders associated with a buildup of protein in the body tissues, such as amyloidosis cannot take Velcade.
  • People who are allergic to boron should not take Velcade.
  • Patients with a medical history of Heart and Lung disease cannot take Velcade.
  • Disorders associated with a buildup of protein in the body tissues, such as amyloidosis are restricted from taking Velcade.

Velcade Injection Side effects

The side effects which may arise due to the usage of Velcade are as follows:

  • Effects on the nerves (peripheral neuropathy) that may cause pins and needles, tingling, burning, painful or numb sensations in the skin or hands and feet.
  • Headache.
  • Shortness of breath.
  • Feeling sick and vomiting.
  • Constipation or diarrhea.
  • Decreased appetite.
  • Rash.
  • Muscle pain.
  • Fatigue.
  • Fever.
  • Shingles

Velcade Injection Interactions and Overdose

This medicine can react with an antibiotic such as clarithromycin, dexamethasone, an antidepressant such as nefazodone, paroxetine, diabetes medicine you take by mouth, an antifungal medication such as clotrimazole, HIV/AIDS medicine such as atazanavir, a barbiturate such as amobarbital, and HIV/AIDS medicine such as atazanavir.

Overdose may cause weakness, bruising or bleeding, pinpoint red spots on your skin, and fainting and these situations should be treated under medical supervision.

 

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