Vinblastine

Generic Name: Vinblastine

Vinblastine is a prescribed medication used for the treatment of cancer cells. It slows the growth of cancer cells and reduces it from spreading in all over the body or blood. It has the active ingredient of Vinblastine sulphate belongs to a group of anticancer medicines called vinca alkaloids. Alkaloids prevent the formation of chromosome (threadlike structure in cells that carries genetic information) spindles necessary for cell duplication at the dividing stage (mitosis) in its life cycle. This medicine is used in most chemotherapy regimens, and the doses are administered in courses at various intervals to allow normal cells to recover from the adverse effects of the anticancer medicines between doses. However, during this period, cancer cells will also recover and start to replicate again. This medicine is used in breast cancer, kidney cancer, Hodgkin’s Disease, Cancer originating in the outermost membranes surrounding the fetus and affecting the womb or the site of pregnancy outside the womb known as choriocarcinoma which is resistant to other medicines and Kaposi's sarcoma which is a form of skin cancer.

How to Use Vinblastine Injections

  • Vinblastine is given as an injection through a needle placed into a vein.
  • This medicine is usually given once every 7 days
  • To be sure your blood cells do not get too low; your blood will need to be tested on a regular basis.

Cautions before Use Vinblastine Injections

  • This injection of this medicine into the spinal cord or intrathecal injection is likely to be fatal. This medicine is for intravenous use only.
  • This medicine is vesicant, i.e. it can cause severe local reactions such as blistering, ulceration and death to skin and tissue should it leak out of the vein (extravasation). Great care must be taken to avoid extravasation when administering this medicine.
  • This medicine should not be used during pregnancy as it may be harmful to the unborn baby.
  • People who are suffering from liver damage are suggested to not to use this medication.

Vinblastine Injections Side Effects

The side effects which may arise due to the usage of Vinblastine are as follows:

  • Constipation
  • Depression
  • Nausea and vomiting
  • Low red blood cell count (anaemia)
  • "Pins and needles" sensation in hands and feet (peripheral neuritis)
  • Loss of appetite
  • Decrease in the number of white blood cells in the blood (leucopenia)
  • Inflammation of the lining of the mouth (stomatitis)
  • Damage to the nerves
  • Reversible hair loss
  • Jaw pain
  • Paralysis or inactivity of the intestine that stops the movement of material through the gut (paralytic ileus)
  • Decrease in the number of platelets in the blood (thrombocytopenia)

Vinblastine Injections Interactions and Overdose

Vinblastine may react with anticancer medication, Bleomycin and cisplatin. Live vaccines include measles, mumps, rubella (MMR), oral polio, chickenpox (varicella), BCG (Bacillus Calmette and Guérin), and nasal flu vaccine should not be given with this medicine. It may also react with antifungal medication such as clotrimazole, heart or blood pressure medication such as diltiazem, cancer medicines such as cisplatin, HIV/AIDS medicine such as atazanavir

Overdose symptoms of Vinblastine may include severe forms of the serious side effects in case of any overdoses the treatment should be under strict medical supervision.

 

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