Generic Name:Thioridazine
Brand Name(s):Mellaril, Mellaril-S

Thioridazine is used for treating schizophrenia in adults and children who have not responded well to other treatments. Although the drug is not a cure for the condition, it can help improve symptoms. This prescription medication comes in tablet form and is generally taken two or four times a day. This medicine is licensed to treat schizophrenia in people who have not responded well to other antipsychotic medications. Occasionally, thioridazine can also be used for treating a number of other conditions, including anxiety, agitation, dementia, and severe depression. Thioridazine has been categorized among the antipsychotic medications. Thioridazine is usually given after other medications have been tried without successful treatment of schizophrenia.

How to Use Thioridazine Tablets

  • Thioridazine comes in tablet form. It is usually taken by mouth two to four times a day.
  • It does not matter if you take the medication with or without food. If thioridazine bothers your stomach, try taking it with food.
  • Thioridazine should be taken at the same times each day to maintain even levels of the drug in your blood.

Cautions before Use Thioridazine Tablets

  • Thioridazine can cause a life-threatening irregular heart rhythm (arrhythmia) called QT prolongation. Because of this risk, thioridazine should be used only when other antipsychotic medications have failed.
  • Thioridazine can cause a life-threatening condition called neuroleptic malignant syndrome (NMS)
  • Thioridazine can cause tardive dyskinesia, a condition involving unusual, uncontrollable body or face movements. The condition can become permanent even if thioridazine is stopped.
  • Thioridazine can impair your mental or physical abilities to drive a car or operate heavy machinery.
  • Thioridazine may increase the risk of seizures in some people.
  • Thioridazine can cause a drop in blood pressure (hypotension). This can cause a person to have lightheadedness or dizziness, or to faint.
  • This medicine is known as a unsafe medication to be taken during pregnancy.

Thioridazine Tablets Side Effects

The side effects which may arise due to the usage of Thioridazine are as follows:

  • Drowsiness
  • Confusion
  • Hyperactivity
  • Lethargy
  • Restlessness
  • Headaches
  • Dry mouth
  • Constipation
  • Blurred vision
  • Difficulty passing urine
  • Nausea, vomiting, or diarrhea
  • Ejaculation problems
  • Loss of appetite
  • Anemia
  • Asthma
  • Weight gain
  • Bizarre dreams

Interactions and Overdose of Thioridazine Tablets

Drug interactions with thioridazine may increase your risk of developing a life-threatening irregular heart rhythm called QT prolongation. During treatment with thioridazine, you should generally avoid drugs that may increase the level of thioridazine in your blood and medicines that may cause QT prolongation. Among the drugs that can potentially lead to thioridazine interactions are tricyclic antidepressants, sertraline, haloperidol, and certain arrhythmia drugs.

Overdose symptoms of Thioridazine may include stomach cramps, extreme dizziness, dry skin, decreased urination, uncontrollable muscle movements, confusion, agitation, feeling hot or cold, fast or pounding heartbeat, fainting, slow heart rate, weak or shallow breathing, and seizure. In these situations people should seek prompt medical support.


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