Differin is a prescription drug that is applied to the skin to treat acne. It is thought to work by reducing inflammation and slowing the rapid growth of skin cells. This medication is typically applied to the affected areas once a day, just before bedtime. Differin is available in the form of a lotion, gel, or cream. Differin has the active ingredient of adapalene which is also known as the generic name of the medicine.

If you have acne, your healthcare provider may prescribe Differin. This medication is approved for use in adults and children as young as 12 years old. When using this medication for acne, your skin may look worse temporarily; it usually takes about a month for skin appearance to improve. There are also a few other uses for Differin, including the treatment of rosacea and fine wrinkles.

How to Use Differin Gel

  • Apply this medication once daily to the affected areas in the evening just before bedtime. Use only a thin layer.
  • Wash your face and/or other affected areas with a mild, soap-free cleanser before applying Differin.
  • Do not apply more than a small amount; using a large amount of this medicine increases the risk of skin irritation without increasing effectiveness.

Cautions before Use Differin Gel

  • You should avoid the use of Differin in contact with the delicate skin around the eyes and mouth.
  • Avoid exposure to sunlight including artificial sunlight, such as sun lamps or tanning booths, as this medication increases your sensitivity to the sun.
  • Some skin irritation, redness, and burning are to be expected when you first start Differin.
  • Generally, people with eczema should Differin this product, as this medication can cause severe skin irritation in people with eczema.
  • If you get a sunburn, stop using Differin until your skin has recovered.
  • Any area of skin treated with Differin should not be waxed, as this may cause skin damage.
  • Differin should not be taken during pregnancy as it can cause harm to the unborn baby.

Differin Gel Side Effects

The side effects which may arise due to the usage of Differin are as follows:

  • Scaling
  • Dryness
  • Redness
  • Persistent burning or stinging
  • Persistent itching

Differin Gel Interactions and Overdose

There are no drug interactions known with Differin but patients should making sure to discuss all possible skin products which they are using including sunscreen, cleansers, moisturizes, cosmetics.

Some of the possible symptoms of an overdose with Differin (adapalene) include significant skin peeling, redness, and discomfort.


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