Generic Name:Fluorouracil
Brand Name(s):Fluoroplex

Fluoroplex skin care cream is a drug that is used to treat conditions of the skin in which there is rapid multiplication (division) of cells, for example, skin cancer. In order to multiply or divide, cells must produce DNA for each new cell. Production of DNA depends on the production of RNA, which serves as a messenger during the production of DNA. Fluoroplex skin cream prevents the formation of RNA, which, in turn, prevents the formation of DNA. As a result, cells cannot multiply. With continued treatment the remaining cells also die. Fluoroplex skin cream is used to treat certain skin conditions in which cells are multiplying rapidly. It is used to treat cancerous or precancerous conditions including solar keratoses, actinic keratosis, and superficial basal cell carcinoma. It also is used to treat some noncancerous conditions in which cells are dividing rapidly, including psoriasis, genital warts, and porokeratosis, which is an unusual inherited skin condition, causing dry patches on the arms and legs. Fluoroplex skin cream works best on the face and scalp and is less effective on other areas of the body. It also destroys sun-damaged skin cells making the skin smoother and more youthful-appearing.

How to Use

Fluoroplex skin cream is applied once or twice daily after washing the area that is to be treated with plain water. The course of treatment continues for up to four weeks. A tiny amount of the cream should be gently rubbed into all of the treated areas with a fingertip. It is important to apply it to all of the skin and not just visible lesions. Afterwards, the finger should be rinsed thoroughly with water. The patients can use gloves if needed.

Cautions before Using

The cautions that are to be followed are as follows:

  • Before using fluoroplex skin cream, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
  • The cautions should be taken with those patients who have a certain enzyme deficiency dihydropyrimidine dehydrogenate – DPD.
  • Do not use other skin products including creams, lotions, medications, or cosmetics with this medication.
  • Stay out of sun while using Fluoroplex skin cream as it may cause damage to the skin or apply sunscreen before going out.

Possible Side Effects

The side effects that may occur due to the use of Fluoroplex skin cream are as follows:

  • With application of fluoroplex skin cream, initially there usually is a mild to severe stinging or burning sensation or irritation.
  • It also sensitizes the skin to sun and promotes sunburn. After five to ten days of treatment, the sun-damaged parts of treated skin can become red and irritated.
  • Fluoroplex skin cream also may cause prolonged hypo-pigmentation or lightening of the skin, which is more noticeable in dark-skinned persons.
  • Certain areas are more sensitive to severe irritation, including skin folds, the lips, and the eyelids.

Reactions and Overdose

Before using this medication, ask your doctor or pharmacist about all prescribed and nonprescribed or herbal products you are using as it may cause reactions with them.

This medicine may be harmful if swallowed. If overdose or swallowing is suspected the patient should be taken to the medical center immediately.


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