Isotretinoin is a skin care drug especially used to treat acne. Isotretinoin may be prescribed to treat severe nodular acne that has not responded well to other acne treatments. This medication comes in capsule form and typically taken twice a day. In many cases, only one 15- to 20-week course of isotretinoin is necessary to treat acne. Before beginning treatment, tell your healthcare provider about any other medications you are taking, including vitamins and supplements.

However, this acne medication is extremely dangerous for pregnant women, and there are strict rules and regulations for prescribing and dispensing it. Isotretinoin is a retinoid, which means that it is similar to vitamin A. It works by affecting the sebaceous glands. These glands produce sebum an oily substance, and Isotretinoin works by reducing the size of the sebaceous glands and decreasing sebum production. The medication also corrects abnormal keratinization, which causes a buildup of cells within hair follicles a problem that contributes to acne. Isotretinoin uses include chemotherapy treatment in certain types of cancer.

How to Use Isotretinoin Capsules

Usually, Isotretinoin is taken for 15 to 20 weeks. Your acne will continue to improve after you stop taking the medication. A second course may be recommended if your acne is still a problem eight weeks after finishing the first course. You will not be able to get more than a 30-day supply of Isotretinoin at a time. Each time you need more, you will need a new prescription and new authorization from the iPLEDGE program the program that is designed to prevent birth defects caused by Isotretinoin. In most cases, the recommended isotretinoin dosage is 0.5 mg to 1 mg per kg of body weight each day, divided into two daily doses. For adults with severe acne or acne limited mostly to the trunk of the body, a dose of 2 mg per kg each day may be necessary.

Cautions before Use Isotretinoin Capsules

  • Some warnings and precautions to be aware of prior to taking Isotretinoin are as follows:
  • This medication is likely to cause severe birth defects if it is taken during pregnancy. It is essential that you not take Isotretinoin while pregnant, and you should not get pregnant while taking it this medication. Isotretinoin may also increase the risk of miscarriages and premature birth.
  • Isotretinoin can cause depression, psychosis, or suicidal behavior. Make sure to let your healthcare provider know if you have had such problems in the past, or even if any of your family members has had such problems.
  • Isotretinoin can cause hepatitis.
  • Some people have experienced hearing problems possibly due to Isotretinoin.

Isotretinoin Side Effects

Some of the side effects are as follows that may occur with Isotretinoin:

  • Headache
  • High Blood pressure
  • Vision Changes
  • Inflammatory bowel disease
  • Abdominal pain
  • Ringing of the ears (tinnitus) or hearing loss
  • Signs of liver damage
  • Seizures
  • Swelling in face, throat and tongue
  • Osteoporosis

Isotretinoin Reactions and Overdose

Several medicines may cause negative drug interactions with Isotretinoin, including certain antibiotics, corticosteroids, and progestin-only birth control pills. These interactions can increase your risk health conditions, such as osteoporosis or pseudotumor cerebri.

Overdose symptoms may include headache, dizziness, vomiting, stomach pain, loss of balance etc.


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