Pimecrolimus skin cream is a chemical that is used to treat atopic dermatitis or eczema. Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers.

Scientists do not know exactly how Pimecrolimus skin cream reduces the manifestations of atopic dermatitis, but Pimecrolimus skin cream reduces the action of T-cells and mast cells, which are part of the immune system and contribute to responses of the immune system. Pimecrolimus skin cream prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulates T-cells. Pimecrolimus skin cream also reduces the ability of mast cells to release chemicals that promote inflammation. Pimecrolimus skin cream was approved by the FDA in December 2001.

How to Use Pimecrolimus Cream

Patients should completely rub in a thin layer of Pimecrolimus skin cream to the affected areas twice daily. An improvement in symptoms can be seen within 8-15 days. Wash your hands with soap and water before using this medication. Apply a thin layer to the affected areas of skin, usually twice daily or as directed by your doctor. Rub the medication into the skin gently and completely. Wash your hands after using this product unless your hands are being treated. If your doctor recommends a moisturizer, apply it after this medication. Pimecrolimus skin cream is for use on the skin only. Avoid getting this medication in your eyes or on the inside of your nose or mouth. Do not apply this medication to open wounds or infected areas.

Cautions before Use Pimecrolimus Cream

The cautions, which are to be followed, are as mentioned under:

  • There have been rare reports of cancers such as skin cancer or lymphoma in patients using Pimecrolimus skin cream. It is not known whether Pimecrolimus caused these cancers when used on the skin, thus, it is better to consult a doctor before taking this medication into use.
  • People with medical history, especially of current infections such as mononucleosis or use of light therapy should avoid.
  • People with medical history of skin infections like shingles, chicken pox and warts.
  • People with medical history with weaker immune system should avoid this medication.
  • Patients should avoid sun exposure, tanning booths and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Pimecrolimus Cream Side Effects

The side effects, which may occur due to the usage of Pimecrolimus skin cream, are as follows:

  • Severe dizziness
  • Trouble in breathing
  • Swelling in face, throat and mouth
  • Headache
  • Fever
  • Skin irritation, redness
  • Rashes
  • Sore throat

Pimecrolimus Cream Reactions and Overdose

Before using this medication, ask your doctor or pharmacist about all prescribed medicines and nonprescribed or herbal products you are using as it may cause reactions with them. It is better not to use any kind of topical or steroidal moisturizer or cream with Pimecrolimus skin cream.

Pimecrolimus skin cream may be harmful if swallowed. If overdose or swallowing is suspected the patient should be taken to the medical center immediately.


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