Creon is a pancreatic enzyme preparation consisting of pancrelipase, an extract derived from porcine pancreatic glands. Pancrelipase contains multiple enzyme classes, including porcine-derived lipases, proteases, and amylases. is a combination of three enzymes (proteins): lipase, protease, and amylase.

These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars. Creon is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts. Creon may also be used in surgical removal of the pancreas.

Creon comes in a beige-white amorphous powder. It is miscible in water and practically insoluble or insoluble in alcohol and ether.

How to use Creon Tablets

  • Creon is usually taken with meals.
  • Do not hold the tablets or capsule contents in your mouth. The medication may irritate the inside of your mouth.
  • Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time.
  • You may open the Creon capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.
  • Do not inhale the powder from a Creon capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

Cautions before Use Creon Tablets

  • If you have a sudden onset of pancreatitis; or any worsening of chronic pancreatic disease then you should not take this medicine.
  • You should not take Creon if you are allergic to pork proteins.
  • Creon should not be taken into use during pregnancy as this medication may be harmful to an unborn baby. Breastfeeding mothers should also discuss with their doctors before taking this medicine.

Creon Tablets Side Effects

The side effects which may arise due to the usage of Creon are as follows:

  • nausea or vomiting;
  • stomach pain or upset;
  • diarrhea or constipation;
  • greasy stools;
  • rectal irritation; or
  • bloating or gas

Creon Tablets Interactions and Overdose

There may be other drugs that can interact with Creon. Patients should inform their doctor about all their prescription and nonprescription medications, vitamins, minerals, herbal products, and dietary supplements.

Overdose symptoms of Creon may include diarrhea or stomach upset. Treatment should include immediate medical support to the patient


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