Depo Testosterone

Depo-Testosterone is a prescription medicine licensed to treat low testosterone levels in men. It comes as an injection that is given in a muscle every two to four weeks in most cases. Because this medicine contains testosterone in a special oil formulation, testosterone is slowly absorbed from the oil into the bloodstream.

Depo-Testosterone has the generic name testosterone cypionate which is a prescription injection approved to treat low testosterone levels in men due to various causes. Because it is an anabolic steroid, it is classified as a controlled substance. If you have low testosterone levels, your healthcare provider may prescribe Depo-Testosterone. Using this medicine can help increase testosterone levels, whether they are due to a problem in the brain or in the testes. In some cases, a healthcare provider may recommend using this drug to treat low testosterone in women or as a hormone therapy in transgender individuals.

How to Use Depo Testosterone Injection

  • The medication is an injection that is given once every two to four weeks. It is typically given into the gluteal muscle.
  • Some men are able to give themselves the injections. Others have a friend or family member give the injection. Others only feel comfortable with a healthcare provider giving the injection. Talk with your healthcare provider about who should give the injections.
  • Depo-Testosterone comes in a vial without any needles or syringes. If you are doing the injections at home, you will also need to purchase needles and syringes. Your pharmacist can help you choose an appropriate needle gauge and length.
  • For the medication to work properly, it must be used as prescribed.

Cautions before Use Depo Testosterone Injection

  • Depo-Testosterone can cause or worsen an enlarged prostate. It also appears to increase the risk for prostate cancer.
  • Depo-Testosterone can potentially decrease sperm count, thereby decreasing fertility.
  • Depo-Testosterone could be very dangerous for pregnant women and breastfeeding mothers.

Depo Testosterone Injection Side Effects

The side effects which may arise due to the usage of Depo-Testosterone are as follows:

  • Breast development
  • Increased frequency and duration of penile erections
  • Low sperm count (especially at high dosages)
  • Body and facial hair growth
  • Male pattern baldness
  • Acne
  • Increased or decreased sex drive
  • Headaches
  • Inflammation and pain at the injection site
  • Infertility
  • Signs of liver damage
  • Depression
  • Prostate Cancer
  • Nausea or vomiting
  • Changes in skin color

Depo Testosterone Injection Interactions and Overdose

Before beginning treatment with Depo-Testosterone, make sure your healthcare provider is aware of any other prescription and nonprescription medications, vitamins, or supplements you are taking. Drug interactions can occur when Depo-Testosterone is combined with insulin, corticosteroids, warfarin, or several other medicines. Some of these reactions may increase your risk for problems, including fluid retention, liver damage, or bleeding.

There has been one report of a serious effect of a stroke which may happen possibly due to a Depo- testosterone overdose. Treatment for a Depo-Testosterone overdose will likely involve medical supportive care.


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