Generic Name: Conjugated estrogens and Medroxyprogesterone

Prempro is a prescription medication approved to treat menopausal symptoms in women who still have a uterus. This medication contains a mixture of natural estrogen hormones, as well as a progestin hormone. Prempro comes in tablet form and is taken once a day. Prempro has the active ingredients of conjugated estrogens and medroxyprogesterone which are combined to make a prescription medication that contains a mixture of natural estrogen hormones along with a progestin hormone.

It is approved for treating certain menopausal symptoms and preventing osteoporosis in postmenopausal women. This prescription hormone medication contains a mixture of natural estrogens and a progestin hormone. The progestin hormone helps decrease the risk of developing cancer of the lining of the uterus. For women without a uterus, the progestin component is usually considered unnecessary.

How to Use Prempro Tablets

  • The medication comes in tablet form. It is taken by mouth once a day.
  • You can take Prempro with or without food. If the medication bothers your stomach, try taking it with food.
  • You can take Prempro at any time of the day, although it is best to take it at the same time each day.
  • For the medication to work properly, it must be taken as prescribed.

Cautions before Use Prempro Tablets

  • Medical reports have been found Prempro increases the risk of heart attack, stroke, and blood clots in the legs and lungs.
  • Prempro) may increase the risk of breast cancer.
  • If you have abnormal vaginal bleeding, such as heavy bleeding or bleeding between periods, while taking Prempro, as this may be a sign of precancerous or cancerous changes in the uterus.
  • Prempro seem to increase the risk of dementia.
  • Prempro should be used with caution in people who have low calcium levels in the blood.
  • Women who take estrogen-containing medications like Prempro have an increased risk for gallbladder disease.
  • Prempro can cause high blood pressure or high thyrioid in some women.
  • If you have an underactive thyroid, Prempro may increase your body’s requirement for thyroid hormones.
  • This medication can make endometriosis symptoms worse.

Prempro Tablets Side Effects

The side effects which may arise due to the usage of Prempro are as follows:

  • Accidental injury
  • Sinus infections
  • Gas
  • Painful menstrual cramps
  • General weakness
  • Coughing
  • Yeast infections
  • Diarrhea
  • Leg cramps
  • Milky white vaginal discharge
  • Vaginal bleeding (bleeding and spotting are more common at first and become less common over time)
  • Dizziness
  • Breast enlargement

Prempro Tablets Interactions and Overdose

To avoid possible drug interactions, with Prempro, talk to your healthcare provider about any other medications you are taking before starting treatment. Drug interactions may occur if Prempro is combined with medications such as barbiturates, some seizure medications, and thyroid medications. Some of these Prempro drug interactions can affect the way your body metabolizes these medicines, possibly increasing your risk of side effects.

A Prempro overdose is likely to cause nausea, vomiting, or vaginal bleeding. If a Prempro overdose occurs, treatment will most likely involve medical supportive care or applying specific medications for the purpose.


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