Zavesca

Generic Name: Miglustat

Zavesca is presently the only approved oral treatment for patients with mild to moderate type 1 Gaucher disease for whom enzyme replacement therapy is unsuitable. Type 1 Gaucher disease is a rare and debilitating metabolic disorder. It has the generic name and also the active ingredient of Miglustat which may reduce the formation of the protein glucosylceramide in the body.

Individuals with type 1 Gaucher disease which is a hereditary disorder are missing an enzyme to break down glucosylceramide in the body. Therefore, it may build up in the tissues and cause problems. Untreated Gaucher disease may result in anemia or the increase of low level of red blood cells, thrombocytopenia or the low level of platelets, bone disease, hepatomegaly or the enlargement of the liver, or splenomegaly known as the enlargement of the spleen.

Zavesca is used in the treatment of mild to moderate type 1 Gaucher disease by people who cannot receive enzyme replacement therapy.

How to Use Zavesca Tablets

  • Take Zavesca exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take Zavesca at the same time or times each day as directed by your doctor.
  • Swallow each capsule whole with a full glass of water.
  • Zavesca can be taken with or without food.
  • It is important to take Zavesca regularly to get the most benefit.

Cautions before Use Zavesca Tablets

  • Zavesca is known to cause birth defects in an unborn baby. Do not take this medicine without first talking to your doctor if you are pregnant or could become pregnant during treatment.
  • Zavesca may commonly cause dizziness. Avoid driving or operating machinery until you know how this medication affects you.
  • Diarrhea is a very common side effect of this medication. If you experience diarrhea, taking Zavesca between meals may help.
  • The safety and effectiveness of using this medication for type I Gaucher disease have not been established in children less than 18 years of age. 
  • The safety and effectiveness of Zavesca have not been evaluated for people with severe Gaucher disease. Zavesca is used for mild to moderate type 1 Gaucher disease.

Zavesca Tablets Side Effects

The side effects which may arise due to the usage of Zavesca are as follows:

  • diarrhea
  • decreased appetite or weight loss
  • gas
  • constipation
  • muscle cramps or weakness
  • headache
  • dizziness
  • vision problems
  • nausea
  • stomach or abdominal pain
  • tremor (shakiness)
  • unusual tiredness
  • vision problems
  • vomiting
  • weakness
  • weight loss

Zavesca Tablets Interactions and Overdose

There are no known interactions between Zavesca and other medications. Talk to your doctor or healthcare provider, before taking any other prescription or over-the-counter medications, including vitamins, minerals, herbal products or any dietary supplements, during treatment with Zavesca.

Symptoms of a Zavesca overdose are not well known but may include dizziness, numbness and tingling, and blood problems. In these conditions the patient must be taken to the doctor immediately.

 

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