Generic Name: Ziconotide

Ziconotide is a prescribed medication and was approved in the form of intrathecal injection was recently approved by the United States Food and Drug Administration (FDA) for the management of severe chronic pain in patients who require intrathecal therapy and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies, or intrathecal morphine. Ziconotide is a non-narcotic pain reliever that works by blocking pain signals from the nerves to the brain.Ziconotide is used to treat severe chronic pain in people who cannot use or do not respond to standard pain-relieving medications.

Chronic malignant pain syndromes, such as those due to advanced cancer, acquired immunodeficiency syndrome (AIDS), and multiple sclerosis, and chronic neuropathy of various etiologies, are some of the most common problems treated with Ziconotide.

How to Use Ziconotide Injection

  • Ziconotide is given as an injection into the space around your spinal cord (intrathecal injection) using a computerized, portable infusion pump to control the rate of medication you receive. You may need to use this medication for a period of many years.
  • Ziconotide must be given only as an intrathecal injection through an infusion pump and should not be injected directly into a vein or other part of the body. Your doctor, nurse, or other healthcare provider will give you this injection.
  • Your doctor may occasionally change your dose or infusion pump flow rate to make sure you get the best results from this medication.

Cautions before Use Ziconotide Injection

  • Severe psychiatric symptoms and neurological impairment may occur during treatment with ziconotide. So, make sure before taking this medicine if you have any mental disorders.
  • You should not use this medication if you are allergic to ziconotide, or if you have an uncontrolled bleeding or blood clotting disorder.
  • Ziconotide is harmful to an unborn baby. Therefore pregnant are advised to not to take this medicine.

Ziconotide Injection Side Effects

The side effects which may arise due to the usage of Ziconotide are as follows:

  • Dizziness
  • Nausea
  • Confusion
  • Nystagmus
  • Headache
  • problems with memory, speech, walking, or thinking;
  • feeling like you might pass out;
  • double vision or other vision problems;
  • new or worsening muscle pain, cramps, soreness, or weakness, and/or dark urine;
  • unusual bleeding or signs of infection around the microinfusion entry or catheter exit sites;
  • fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, nausea, vomiting, and/or seizure (convulsions);
  • extreme drowsiness or tired feeling, depressed mood;
  • feeling paranoid, hostile, disoriented, or confused;
  • strange sensations in your mouth;
  • hallucinations, unusual thoughts or behavior, thoughts of hurting yourself; or
  • feeling less alert, decreased consciousness

Ziconotide Injection Interactions and Overdose

Before receiving ziconotide, do not use if you regularly use other medicines that make you sleepy such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety. Ziconotide can add to sleepiness caused by these other medications.

Overdose symptoms may include extreme drowsiness, vision problems, confusion, speech problems, stiffness in your neck or back, nausea and vomiting, or loss of consciousness. In these situations patients should require medical attention.


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