Generic Name: Retrovir

Zidovudine is a medicine that is prescribed to treat HIV and AIDS. It is comes in the form of injection used for preventing the transmission of the HIV virus from a pregnant woman to her unborn child. Zidovudine, which is typically used in combination with other HIV medications, is available in tablets, capsules, and syrup. Zidovudine has the active ingredient of Retrovir which is a prescription medication used to treat HIV infection and AIDS. It is approved to treat HIV and to help prevent pregnant women with the virus from spreading it to their babies.

Zidovudine was the first HIV medication approved by the U.S. Food and Drug Administration (FDA). It is also known as azidothymidine (AZT for short) or ZDV. Zidovudine is used for treating HIV and AIDS in both adults and children as young as three months old. It is also approved to help prevent the transmission of HIV from an infected pregnant woman to her unborn child. Off-label zidovudine uses may include the treatment of thrombocytopenia in people with HIV and T-cell lymphoma or leukemia.

How to Use Zidovudine Injection

  • The medication comes in several forms, including tablets, capsules, and syrup. It is taken by mouth two to five times a day, depending on several factors.
  • Zidovudine also comes in an injectable form that is given by IV, often during labor to help prevent the transmission of HIV from a mother to her baby.
  • You can take zidovudine with or without food. If the medicine bothers your stomach, try taking it with food.
  • For the medication to work properly, it must be taken as prescribed. It is very important that you closely follow your healthcare provider’s instructions about taking zidovudine. Missing doses can increase the chances of the virus developing resistance to the drug thereby making it less effective.

Cautions before Use Zidovudine Injection

  • The medication can cause bone marrow depression, which means that it can decrease the bone marrow’s ability to produce blood cells. This can lead to a variety of problems, such as anemia, frequent infections, or bleeding.
  • zidovudine can cause a condition called lactic acidosis and hepatic steatosis. It is caused by damage to the liver and can be dangerous.
  • Zidovudine can cause muscle problems.
  • Zidovudine is not a cure for HIV or AIDS.

Zidovudine Injection Side Effects

The side effects which may arise due to the usage of Zidovudine are as follows:

  • Headaches
  • A general ill feeling
  • Nausea
  • Loss of appetite
  • Vomiting
  • Abdominal (stomach) cramps or pain
  • Joint pain
  • Chills
  • Indigestion or heartburn
  • Fatigue
  • Insomnia
  • Muscle or bone pain
  • Nerve problems, such as unusual sensations

Zidovudine Injection Interactions and Overdose

Ganciclovir, atovaquone, and methadone are some of the medications that may cause drug interactions with zidovudine. These interactions can either increase the level of zidovudine in your blood and increase your risk of side effects or decrease the level of zidovudine in your blood and reduce the medication’s effectiveness. Other medicines that may lead to drug interactions with zidovudine include probenecid, ritonavir, and stavudine.

In case of any overdose effects people should get immediate medical attention.


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